Serocorrelates of protection against infant group B streptococcus disease
نویسندگان
چکیده
منابع مشابه
Human monoclonal antibodies to group B streptococcus. Reactivity and in vivo protection against multiple serotypes
Group B streptococcal (GBS) infections cause significant mortality and morbidity among infants. Passive antibody immunotherapy has been proposed as treatment for infected infants. To this end, two human mAb-secreting cell lines were produced by EBV immortalization of human B cells. The mAbs were specific for the group B polysaccharide and bound to strains of all five serotypes as demonstrated b...
متن کاملMouse protection test for group B Streptococcus type III.
The mouse model has been used previously for the study of protection against challenge with strains of group B Streptococcus types Ia, Ib, and Ic, but investigators have not yet been successful in causing lethal disease when type III strains are inoculated. In this study, six clinical isolates belonging to serotype III were lethal in seven-week-old outbred albino mice; the 50% lethal dose (LD50...
متن کاملInvestigation of Betahemolytic Streptococcus Group B in Natural Vaginal Flora
This article has no abstract.
متن کاملProtection against group B meningococcal disease. I. Comparison of group-specific and type-specific protection in the chick embryo model
Protection against group B meningococcal infection was examined using the chick embryo. 12-day-old embryos were challenged intravenously with various meningococcal strains. The chick embryo has an active reticuloendothelial system but lacks functional complement. In this model we found that protection against group B infection was primarily group specific. The group B polysaccharide antibody is...
متن کاملConjugate vaccines against group B Streptococcus types IV and VII.
Although rarely encountered, group B Streptococcus (GBS) types IV and VII have been isolated from infants and adults with invasive disease. This study was designed to determine the immunogenicity and efficacy in animals of conjugate vaccines prepared with GBS types IV and VII capsular polysaccharide (CPS). Despite the striking similarities in structure of these 2 carbohydrate antigens, high-tit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2019
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(18)30659-5